Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them

摘要

The present invention is to provide manufacturing intermediates which can be led to useful alpha -ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino alcohol compounds represented by the following formulae: wherein R<1> and R<2> each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R<3> represents alkyl group, alkenyl group, aromatic hydrocarbon group, heterocyclic group, R<6>-O- or R<7>-N(R<8>)-; where R<6> represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R<7> and R<8> each represents hydrogen atom, alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group, and, R<4> and R<5> represent the same groups as R<7> and R<8>, respectively, and R<4> and R<5> optionally form a ring together; and X represents -O- or -N(R<9>)-, where R<9> represents hydrogen atom or alkyl group, and X optionally forms a ring together with R<4> or R<5>, and processes for preparing alpha -keto amide compound using the same.