Process for preparation of terbinafine and its hydrochloride as an antifungal agent

摘要

The present invention provides a novel process for preparing terbinafine represented by the formula (I) and its hydrochloride salt represented by the formula (Ia), which show broad spectrum inhibiting activities against squalene epoxidase of fungus and thus are useful as anti-fungal agents. The process of the present invention can produce terbinafine and its hydrochloride salt in a good yield (about from 60 to 80%) and with a high purity by using a palladium catalyst system effectively at each reaction step, thereby carrying out the process effectively in one reactor within a relatively short time.