| 摘要 |
A novel human G protein-coupled receptor (GPcR) protein, IGPcR27, is identified and characterized. IGPcR27-encoding nucleotides, IGPcR27 proteins and fusion proteins, antibodies to the receptor, host cell expression systems, animal models in which the IGPcR27 gene is mutated, recombinant knock-out animals that do not express IGPcR27 and transgenic animals that express an IGPcR27 transgene are encompassed by the invention, as are compounds that modulate gene expression or receptor activity of IGPcR27 and their use for drug screening, and diagnosis or treatment of diseases and disorders, particularly central nervous system disorders. |
