PROCESS FOR ALKYLATION OF BENZODIAZEPINDIONE COMPOUNDS

摘要

The subject invention involves processes for selective monoalkylation or dialkylation of benzodiazepin-2,5-dione compounds which are unsubstituted in the 1- and 4-positions, and monoalkylation of such compounds already substituted in the 1-position, by reacting them with alkyl bromide or alkyl iodide in the presence of potassium fluoride on alumina in either dimethylformamide or dimethoxyethane solvent. It also involves making libraries of compounds using such processes.