发明名称 |
CHIMERIC PROMOTERS FOR CONTROLLING EXPRESSION IN SMOOTH MUSCLE CELLS |
摘要 |
The present invention concerns a chimeric construct comprising a SMC-specific promoter operably linked to a muscle-specific enhancer. It also provides an expression cassette comprising such a chimeric construct to control expression of a therapeutic gene. Finally, the invention relates to a recombinant vector, a viral particle, an eukaryotic host cell, a composition comprising said expression cassette and their use for specific expression in SMCs and for therapeutic or prophylactic purposes, a method for the treatment of a human or animal organism as well as a transgenic non-human animal comprising integrated into its genome the chimeric construct, the expression cassette or the vector of the present invention. |
申请公布号 |
CA2414328(A1) |
申请公布日期 |
2002.01.10 |
申请号 |
CA20012414328 |
申请日期 |
2001.07.04 |
申请人 |
TRANSGENE S.A. |
发明人 |
RIBAULT, SEBASTIEN;NEUVILLE, PASCAL;MEHTALI, MAJID |
分类号 |
A01K67/027;A01K67/00;A61K31/7088;A61K35/76;A61K38/00;A61K38/21;A61K38/43;A61K48/00;A61P9/00;C07K14/47;C12N5/10;C12N7/00;C12N15/09;C12N15/11;C12N15/85;C12N15/86;C12N15/861 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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