NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN AND DNA THEREOF

摘要

A novel G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 or its salt; a polynucleotide encoding the same; and use thereof in, for example, drugs. This G protein-coupled receptor protein, its peptide fragment, its salt, and a polynucleotide encoding this receptor protein or its peptide fragment are usable in determining a ligand (an agonist), acquiring an antibody and an antiserum, constructing a recombinant receptor protein expression system, developing a receptor-bonded assay system and screening a candidate compound for a drug by using this expression system, designing a drug based on a comparison with a ligand receptor having a similar structure, a reagent for preparing a gene therapy probe and a PCR primer, constructing a transgenic animal, and a drug such as a preventive or a remedy.