FIVE-MEMBERED-RING COMPOUND

摘要

A five-membered-ring compound represented by the formula or a salt thereof: wherein X represents oxygen or sulfur; R<1> represents hydrogen, (un)substituted alkyl, etc.; R<2> represents hydrogen, (un)substituted alkyl, (un)substituted aryl, etc.; Y<1> represents a single bond, (un)substituted alkylene, -CO(CH2)n-, etc.; the wavy line means the (E) or (Z) configuration; R<3> represents (un)substituted aryl, etc.; Y<2> represents (un)substituted alkylene, etc.; R<4> represents hydrogen, (un)substituted alkanoyl, (un)substituted alkyl, etc.; and R<5> represents hydrogen, etc. They inhibit infiltration of leukocytes such as eosinocytes and lymphocytes, and are hence useful for the treatment of various kinds of inflammation.