发明名称 |
Presentation of hydrophobic antigens to T-cells by CD1 molecules |
摘要 |
Provided are CD1 presented antigens, compositions, cells, inhibitors and methods relating to the use of lipoarabinomannan (LAM) antigen presentation by CD1 molecules, including: methods for detecting the presence of a CD1-presented LAM antigen in a sample; methods for isolating such CD1-presented LAM antigens and the isolated antigens; vaccines containing CD1-presented LAM antigens and vaccination methods; methods of blocking CD1 LAM antigen presentation; methods of identifying and/or isolating CD1 blocking agents and the isolated CD1 blocking agents; methods of inducing CD1 expression; and T-cells for use in the methods disclosed herein. |
申请公布号 |
EP1170592(A1) |
申请公布日期 |
2002.01.09 |
申请号 |
EP20010202176 |
申请日期 |
1995.10.13 |
申请人 |
BRIGHAM AND WOMEN'S HOSPITAL;UNIVERSITY OF CALIFORNIA, LOS ANGELES;COLORADO STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
MODLIN, ROBERT L.;SIELING, PETER A.;BRENNER, MICHAEL B.;BRENNAN, PATRICK J.;PORCELLI, STEVEN A.;FURLONG, STEPHEN T. |
分类号 |
G01N33/53;A61K39/04;A61K47/48;C07K14/74;C07K16/28;C08B37/00;C12N5/10;C12P19/04;C12Q1/02;G01N33/566 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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