发明名称 |
Statement as to federally sponsored research |
摘要 |
Novisprin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced <i>in vitro</i> cytotoxicity relative to other antimicrobial peptides, and were well-tolerated <i>in vivo</i> after intravenous injection. Novispirins also bind lipopolsaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections. |
申请公布号 |
AU6842101(A) |
申请公布日期 |
2002.01.08 |
申请号 |
AU20010068421 |
申请日期 |
2001.06.13 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,;THE UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
ROBERT I LEHRER;ALAN J. WARING;BRIAN F. TACK |
分类号 |
A61K9/12;A61K38/00;A61K45/00;A61K47/12;A61P31/04;A61P31/06;A61P31/08;A61P31/10;A61P33/02;A61P33/04;A61P33/06;A61P43/00;C07K7/08 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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