发明名称 |
Process for the preparation of tetrahydroindolizines |
摘要 |
Described is a process for the preparation of Compound (7) in accordance with the following reaction scheme by reacting Compound (5) with ethylene glycol in a solvent in the presence of a Lewis acid, thereby obtaining Compound (6), and then reacting the resulting compound with a carbonate diester in a solvent in the presence of a metal alkoxide (R1, R6 each represents a C1-6 alkyl group or the like and R5 represents H or C1-5 alkyl group).Compound (7) so obtained is useful as an intermediate for camptothecins useful as antitumor agents.
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申请公布号 |
US6337400(B1) |
申请公布日期 |
2002.01.08 |
申请号 |
US20000640879 |
申请日期 |
2000.08.18 |
申请人 |
DAIICHI PHARMACEUTICAL CO., LTD. |
发明人 |
KAMIHARA SHINJI;KANAI KAZUAKI;NOGUCHI SHIGERU |
分类号 |
C07D471/04;C07D491/20;(IPC1-7):C07D221/02 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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