发明名称 |
Use of egf-r protein tyrosine kinase inhibitors for preventing photoaging in human skin |
摘要 |
Photoaging of human skin, such as evidenced by the increased presence of matrix metalloproteinases after exposure to UV radiation, is prevented by pre-treating the skin with an inhibitor of epidermal growth factor receptor (EGF-R) prior to exposure. Such inhibitor are preferably natural, an example of which is genistein. Compositions used for such purposes preferably include an EGF-R as well as another MMP inhibitor, such as a retinoid. |
申请公布号 |
AU7202801(A) |
申请公布日期 |
2002.01.08 |
申请号 |
AU20010072028 |
申请日期 |
2001.06.26 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
JOHN J VOORHEES;GARY J. FISHER |
分类号 |
A61K8/00;A61K8/49;A61K31/07;A61K31/203;A61K31/352;A61P17/16;A61P43/00;A61Q17/04;A61Q19/08 |
主分类号 |
A61K8/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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