METHOD FOR OBTAINING PROTECTIVE ANTIGENS AGAINST BORDETELLA INFECTIONS AND TOXIC PROCESSES

摘要

The invention relates to adenylate cyclase preparations comprising at least one adenylate cyclase selected from the group consisting of an active adenylate cyclase having a molecular weight (Mr) of about 43 ~ 4.3 - 45 ~ 4.5 kDa or an inactive adenylate cyclase having a molecular weight (Mr) of about 43 ~ 4.3 kDa Preferably, the active and inactive adenylate cyclase are obtained from B.parapertussis. The invention also relates to vaccine compositions for preventing infections caused by Bordetella which comprise the adenylate cyclase preparations referred to previously.