发明名称 |
Intramolecularly-quenched near infrared fluorescent probes |
摘要 |
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging. |
申请公布号 |
AU7138001(A) |
申请公布日期 |
2002.01.08 |
申请号 |
AU20010071380 |
申请日期 |
2001.06.22 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
RALPH WEISSLEDER;CHING-HSUAN TUNG;UMAR MAHMOOD;LEE JOSEPHSON;ALEXEI BOGDANOV |
分类号 |
A61B5/00;A61K47/48;A61K49/00;C07K7/06 |
主分类号 |
A61B5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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