PREPARATION METHOD OF 3-HYDROXYPROPIONIC ACID OR ITS SALT FROM EPOXIDE DERIVATIVE

摘要

PURPOSE: A method for preparing 3-hydroxypropionic acid or its salt from an epoxide derivative is provided, to improve the production yield by using the catalysis system with high activity and selectivity, comprising a cobalt catalyst and an accelerating agent. CONSTITUTION: The method comprises the steps of reacting an epoxide, CO and an alcohol in solvent by using a catalytic amount of a cobalt compound and an accelerating agent at a temperature of 30-150 deg.C and a pressure of 50-3,000 psig, to prepare β-hydroxyester and its derivatives; separating the product and a solvent from the catalyst and the accelerating agent; and hydrolyzing the separated product in the presence of an acid or a base to obtain 3-hydroxypropionic acid. Preferably the accelerating agent is an imidazole derivative. The acid or the base is dipped into a solid supporter comprising charcoal and silica, and the hydrolysis is carried out under the nitrogen, argon or air atmosphere at a temperature of 20-110 deg.C.