| 摘要 |
Preparation of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetic acid, its acid addition salts and metal salts involves hydrolysis of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetamide (I) or its acid addition salts in alkaline or acidic medium and optionally in the presence of a phase transfer catalyst. Preparation of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetic acid, its acid addition salts and metal salts involves hydrolysis of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetamide of formula (I) or its acid addition salts in alkaline or acidic medium and optionally in the presence of a phase transfer catalyst. R1 and R2 = 1-4C alkyl optionally substituted by a phenyl, 2-4C alkenyl or cyclohexyl; R1+R2+N = morpholine. Independent claims are also included for: (1) (I) and its acid addition salts; and (2) preparation of (I). |
