摘要 |
The invention relates to bicyclic pyrimidine derivatives, capable of inhibiting the tyrosine kinase receptors of epidermal growth factor, which have a structure corresponding to the general formula (I), wherein at least one and as many as three of A-E atoms are nitrogen atoms, and the remaining atoms are carbon atoms, X represents O, S, NH or NR7, and R7 is lower alkyl having 1...4 carbon atoms, n is 0,1,2; R1 is a hydrogen atom or a lower alkyl group having 1...4 carbon atoms, R2 is a lower alkyl with 1...4 carbon atoms, m is 0 ...3, R3, R4, R5 and R6 are separately H, lower alkyl, cycloalkyl, R6 is hydrogen or lower alkyl or pharmaceutic salt or the hydrate thereof. At the same time, the invention also comprises a pharmaceutical composition which contains the compound having the formula (I) as active ingredient, as well as a method for inhibiting the tyrosine kinase receptor of the epidermal growth factor.
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