The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
申请公布号
WO0198361(A2)
申请公布日期
2001.12.27
申请号
WO2001US20153
申请日期
2001.06.22
申请人
GENENTECH, INC.;DEVAUX, BRIGITTE;HONGO, JO-ANNE, S.;PRESTA, LEONARD, G.;SHELTON, DAVID, L.
发明人
DEVAUX, BRIGITTE;HONGO, JO-ANNE, S.;PRESTA, LEONARD, G.;SHELTON, DAVID, L.