| 发明名称 |
POSITIVELY-CHARGED PEPTIDE NUCLEIC ACID ANALOGS WITH IMPROVED PROPERTIES |
| 摘要 |
The present invention relates to novel types of peptide nucleic acids (PNAs) with improved properties. In particular, it relates to positively charged PN A units having an ethylene linker between the backbone and the nucleobase, to oligonucleotide analogs comprising these units, to oligomers comprising thes e units, and to the use of positively charged PNAs as novel delivery agents wi th therapeutic and diagnostic applications including for antisense therapy.</SD OAB>
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| 申请公布号 |
CA2413556(A1) |
申请公布日期 |
2001.12.27 |
| 申请号 |
CA20012413556 |
申请日期 |
2001.06.22 |
| 申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM</S |
发明人 |
GIBSON, DAN;SCHLOSSMAN, ADA;NAJAJREH, YOUSUF;KATZHENDLER, JEHOSHUA |
| 分类号 |
C12N15/09;A61K38/00;A61K47/48;A61K48/00;A61P9/00;A61P25/28;C07D239/47;C07D473/18;C07D473/34;C07K2/00;C07K14/00;(IPC1-7):C07H21/04;C12N15/00 |
主分类号 |
C12N15/09 |
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