| 摘要 |
chemical-pharmaceutical industry. SUBSTANCE: invention relates to pharmaceutical microspherical particles of valproic acid designated for oral administration. Pharmaceutical microspherical particles have a mixture of valproic acid and one of its pharmaceutically acceptable salts in combination with matrix carrier as an active component. Matrix carrier is taken among glycerol esters, hydrogenated oils, esterified polyethylene glycols or wax and their mixtures. Invention provides to prepare medicinal form of valproate sodium that can be used in pediatrics and therapy for adult patients since said medicinal form provides masking unpleasant taste of drug. EFFECT: improved properties of drug. 22 cl, 3 dwg, 15 ex |
