发明名称 |
PROCESS FOR THE PREPARATION OF PURE CITALOPRAM |
摘要 |
A process for the preparation of citalopram of formula (I) in which a compound of formula (II) wherein Z is iodo, bromo, chloro or CF3-(CF2)n-SO2-O- n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction in which the group Z is exchanged with cyanide by reaction with a cyanide source; the resultant crude citalopram product is optionally subjected to some initial purification and the crude citalopram base is subsequently subjected to a film distillation process; the resulting citalopram product is then optionally further purified and worked up and isolated as the base or a pharmaceutically acceptable salt thereof.
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申请公布号 |
WO0147877(A3) |
申请公布日期 |
2001.12.27 |
申请号 |
WO2001DK00148 |
申请日期 |
2001.03.07 |
申请人 |
H. LUNDBECK A/S;CASTELLIN, ANDREA;VOLPE, GIULIO;SBROGIO, FEDERICO |
发明人 |
CASTELLIN, ANDREA;VOLPE, GIULIO;SBROGIO, FEDERICO |
分类号 |
A61P25/24;C07D307/87;(IPC1-7):C07D307/87 |
主分类号 |
A61P25/24 |
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