INFLUENZA VIRUS BINDING, SIALYLATED OLIGOSACCHARIDE SUBSTANCE AND USE THEREOF

摘要

The present invention is directed to human influenza virus binding substance containing at least one oligosaccharide chain, which comprises a terminal NeuNAc alpha 6 linked to: (a) a linear or branched polylactosamine type structure consisting of at least three lactosamine residues, a linear sequence optionally containing one or two alpha 3-linked fucose residues in a non-sialylated lactosamine, a branched structure optionally carrying one or more additional NeuNAc alpha -residues at a terminal position in a branch, and/or (b) a linear or branched structure with two lactosamine and one lactose residue, a linear structure in addition containing one or two alpha 3-linked fucose residues in a non-sialylated lactoseamine or lactose, a branched structure optionally carrying one additional NeuNAc alpha -residue in a terminal position of the branch, or an analog or derivative of said oligosaccharide chain for use in binding of human influenza virus.