TABLET SHAPES TO ENHANCE GASTRIC RETENTION OF SWELLABLE CONTROLLED-RELEASE ORAL DOSAGE FORMS

摘要

The retention of oral drug dosage forms in the stomach is improved by using swellable dosage forms that are shaped in a manner that will prevent them fr om inadvertently passing through the pylorus as a result of being in a particul ar orientation. The planar projection of the shape is one that has two orthogon al axes of different lengths, the longer being short enough to permit easy swallowing prior to swelling while the shorter is long enough within one-hal f hour of swelling to prevent passage through the pylorus.