发明名称 |
Three-dimensional in vitro model of human preneoplastic breast disease |
摘要 |
A three-dimensional in vitro culture system comprising breast epithelial cells, endothelial cells and breast fibroblasts supports growth and functional differentiation of preneoplastic breast epithelial cells and endothelial cells and recapitulates estrogen induced in vivo effects on angiogenesis and proliferative potential of breast epithelial tissue. This model permits the generation of functional vascular networks and local proliferative ductal alveolar outgrowths with invasive potential. Both these processes are augmented by estrogen. This culture model is used to evaluate agents for their effects, whether stimulatory or inhibitory, on preneoplastic breast disease and its progression to cancer.
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申请公布号 |
US2001055804(A1) |
申请公布日期 |
2001.12.27 |
申请号 |
US20010759365 |
申请日期 |
2001.01.16 |
申请人 |
SHEKHAR MALATHY P.V.;TAIT LARRY |
发明人 |
SHEKHAR MALATHY P.V.;TAIT LARRY |
分类号 |
C12N5/071;(IPC1-7):C12N5/06;C12N5/08 |
主分类号 |
C12N5/071 |
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