POSITIVELY-CHARGED PEPTIDE NUCLEIC ACID ANALOGS WITH IMPROVED PROPERTIES

摘要

The present invention relates to novel types of peptide nucleic acids (PNAs) with improved properties. In particular, it relates to positively charged PNA units having an ethylene linker between the backbone and the nucleobase, to oligonucleotide analogs comprising these units, to oligomers comprising these units, and to the use of positively charged PNAs as novel delivery agents with therapeutic and diagnostic applications including for antisense therapy.