| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for searching a compound for releasing inhibition of cell proliferation by use of a cell having the property of its function being inhibited in the activation of a spindle check point in which a protein having the activity of inhibiting the cell multiplication in the excessive manifestation is forcedly made to excessively manifest, or a cell having the property of its function being inhibited in the activation of the spindle check point in which the modified body of the protein having the activity of inhibiting the cell proliferation is made to manifest. SOLUTION: In this method, a compound for inducing the cell proliferation inhibition or cell death by inducing a spindle forming abnormality in a cell where an abnormality is caused in the spindle check point such as cancer cell or the like, and activating the spindle check point of this cell can be quickly and easily selected, and a new type of antitumor agent can be obtained.
|
