| 摘要 |
PROBLEM TO BE SOLVED: To obtain a drug capable of inhibiting a 20-hexaeicosatetraenoic acid (20-HETE)-producing enzyme associated with microvascular vasoconstriction, vasodilator, cell growth eliciting actions, etc., in main organs such as the kidney, cerebral blood vessels, etc. SOLUTION: This compound is represented by the formula, wherein at least one of X1 to X5 is each independently nitrogen atom; n is an optional integer of 0-5; Rs are each independently the same or different and denote various kinds of chain, branched or cyclic substituent groups or the adjacent Rs together are capable of forming a ring which may contain 1 or 2 nitrogen atoms when n is >=2 or its pharmaceutically acceptable salt and the medicine is characterized as comprising the compound or the pharmaceutically acceptable salt as an active ingredient.
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