发明名称 |
CD4 gene regulatory sequences specifically expressed in mature T cells |
摘要 |
The present invention relates to compositions and methods for the expression of nucleic acids or polypeptides into mature T lymphocytes. The invention relates more specifically to methods of selective gene expression into mature T lymphocytes, based on CD4-derived regulatory sequences, such as CD4-derived enhancer sequences. The invention is particularly suited for regulating gene expression into mature T lymphocytes in vitro, ex vivo or in vivo, upon genetic modification of hematopoietic precursors and maturation thereof.
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申请公布号 |
US6333171(B1) |
申请公布日期 |
2001.12.25 |
申请号 |
US19980000127 |
申请日期 |
1998.01.16 |
申请人 |
UNIVERSITE PIERRE ET MARIE CURIE |
发明人 |
KLATZMANN DAVID;SALMON PATRICK;BOYER OLIVIER |
分类号 |
C12N15/09;A61K31/00;A61K48/00;A61P31/00;A61P31/12;A61P31/18;A61P37/00;A61P37/02;C07K14/73;C12N5/10;C12N9/12;(IPC1-7):C12P21/06;C12N15/64;C12N5/06;A61K31/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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