发明名称 |
Liposomes containing oligonucleotides |
摘要 |
It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5'-GTGCTCCATTGATGC-3' (seq. ID No. 1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.
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申请公布号 |
US6333314(B1) |
申请公布日期 |
2001.12.25 |
申请号 |
US20000482084 |
申请日期 |
2000.01.13 |
申请人 |
GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
KASID USHA;GOKHALE PRAFULLA;DRITSCHILO ANATOLY;RAHMAN AQUILUR;ZHANG CHUANBO |
分类号 |
A61K9/127;A61K38/00;C07H21/00;C12N15/113;(IPC1-7):A01N43/04;C12Q1/68;C12P19/34;C12N15/63;C07H21/04 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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