发明名称 SEX-ASSOCIATED MEMBRANE PROTEINS AND METHODS FOR INCREASING THE PROBABILITY THAT OFFSPRING WILL BE OF A DESIRED SEX
摘要 A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma- membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies'binding to X- or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing a sperm from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- and Y-sperm. Methods of increas- ing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.
申请公布号 CA1341328(C) 申请公布日期 2001.12.25
申请号 CA19890602086 申请日期 1989.06.07
申请人 CYTOGAM, INC. 发明人 SPAULDING, GLENN F.
分类号 C07K14/705;C07K16/28;C12N5/00;C12N5/06;G01N33/68;(IPC1-7):A61D19/00;G01N33/566;C07K14/47;A61D19/02;C12N5/08;A61K38/17;C07K16/18 主分类号 C07K14/705
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