| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for inhibiting squalene synthetase, capable of readily selecting a compound inhibiting a squalene synthetase and carrying out drug design by utilizing mutual action of hydrophobic property in active center of squalene synthetase and useful for development of therapeutic agent for hypercholesterolemia. SOLUTION: This method for inhibiting a squalene synthetase comprises carrying out hydrophobic mutual action by carrying out van der Waals contact with the following region of squalene synthetase: (1) a hydrophobic region comprising Val 179, Leu 183, Met 207, Gly 208, Leu 211, Tyr 276, Phe 288 and Pro 292 and (2) Phe 54, Val 69, Phe 72, Tyr 73, Leu 76, Val 179, Leu 183 and Phe 288.
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