| 发明名称 |
Methods of replicating a DNA molecule for repair of DNA lesion damage or for mutagenesis |
| 摘要 |
UmuC is found to be a translesion replication DNA polymerase which replicates in the presence of UmuD', RecA and SSB through a DNA lesion of damaged DNA molecule and which is found to be highly mutagenic during in vitro gap-filling replication. A method for replicating a DNA molecule with DNA lesion damage and a method for mutagenesis of a DNA molecule are provided.
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| 申请公布号 |
US6333178(B1) |
申请公布日期 |
2001.12.25 |
| 申请号 |
US20000660552 |
申请日期 |
2000.09.12 |
| 申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
LIVNEH ZVI;REUVEN NINA BACHER;TOMER GUY |
| 分类号 |
C07K14/47;C12N9/12;C12N15/10;(IPC1-7):C12P19/34;C12Q1/68 |
主分类号 |
C07K14/47 |
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