| 摘要 |
1. Transdermal therapeutic system for application to the skin and/or mucosa consisting of at least one active substance in the form of a solid dispersion is combination with at least one destructuring agent and/or at least one structuring agent in a common matrix. 2. Transdermal therapeutic system according to Claim 1, characterized in that the solid dispersion is a molecular dispersion of the active substance in an inert carrier substance. 3. Transdermal therapeutic system according to Claim 2, characterized in that the inert carrier substance is selected from inert carriers known per se for solid dispersions, such as, for example, sucrose, lactose, succinic acid, polyethylene glycols, polyvinyl-pyrrolidone, urea, mannitol, mannitose or mixtures thereof. 4. Transdermal thereapeutic system according to any of Claims 1 to 3, characterized in that the destructuring agent is selected from the group of carboxamides such as urea, nicotinamide, succinamide, methylacetamide, ethylacetamide or mixtures thereof. 5. Transdermal therapeutic system according to Claim 4, characterized is that the relaxation time is more than 120 ms, preferably more than 150 ms. 6. Transdermal therapeutic system according to any of Claims 1 to 5, characterized in that the structuring agent is selected from the group of polyols such as, for example, glycerol, ethylene glycol, propylene glycol, from the group of sugar alcohols such as, for example, sorbitol and/or from the group of sugars such as, for example, sucrose or glucose or mixtures thereof. 7. Transdermal therapeutic system according to Claim 6, characterized in that the relaxation time is less than 119 ms, preferably less than 80 ms. 8. Transdermal therapeutic system according to any of the preceding claims, characterized in that the ratio between destructuring agent and structuring agent is from 10:1 to 1:10. 9. Transdermal therapeutic system according to Claim 8, characterized in that the ratio between destructuring agent and structuring agent is from 2:1 to 1:2. 10. Transdermal therapeutic system according to any of the preceding claims, characterized in that the active substance is selected from hormones, immunomodulators, immunosuppressants. antibiotics, cytostatics, diuretics, gastrointestinal agents, cardiovascular agents and neuropharmaceuticals or mixtures thereof. 11. Transdermal therapeutic system according to Claim 10, characterized in that the active substance is selected from hormones such as testosterone, estradiol, estriol, norethisterone, dienogest or mixtures thereof. 12. Transdermal therapeutic system according to any of Claims 1 to 11, characterized in that the matrix is a sheet-like adhesive piece of material, a plaster, a patch, a gel, an ointment, a cream, an emulsion, an embrocation, a paint or impregnated fabric. |
