| 摘要 |
The invention relates to the reduction of (hetero)aromatic halogenides of general formula (I) Ar-X n to compounds of general formula (II) Ar-H n. To achieve this, a reduction agent is used, in particular a hydride reactant such as lithium aluminium hydride (LiAlH 4) in the presence of oxygen, in particular in the form of an oxygen-inert gas mixture. Reduction in the presence of oxygen gives a good yield in short reaction times, even when working on a semi- industrial or industrial basis. Reduction using LiAlH 4 in the presence of oxygen can also be used to reduce complicated heteroaromatic halogenides, for instance for reducing bromonarwedine ketone acetal to narwedine ketone acetal on an industrial scale. |
