发明名称 |
NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS |
摘要 |
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis. |
申请公布号 |
WO0195859(A2) |
申请公布日期 |
2001.12.20 |
申请号 |
WO2001US17950 |
申请日期 |
2001.06.05 |
申请人 |
CALYX THERAPEUTICS, INC.;NEOGI, PARTHA;NAG, BISHWAJIT;MEDICHERLA, SATYANARAYANA;DEY, DEBENDRANATH |
发明人 |
NEOGI, PARTHA;NAG, BISHWAJIT;MEDICHERLA, SATYANARAYANA;DEY, DEBENDRANATH |
分类号 |
A61K31/426;A61P1/04;A61P3/04;A61P3/06;A61P3/10;A61P5/26;A61P9/10;A61P13/12;A61P17/00;A61P17/06;A61P21/04;A61P25/00;A61P29/00;A61P35/00;A61P37/00;A61P37/08;A61P43/00;C07D277/20;C07D277/24;C07D277/34 |
主分类号 |
A61K31/426 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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