CANDIDA HEMOLYSIN - LIKE PROTEINS AND THEIR USES

摘要

Candida yeast such as C. glabrata, express a hemolysin-like protein (HLP) that is structural similarity to hemolysins in other pathogens. HLP polypeptides are antigenic and are useful as vaccine components to raise a protective immune response against Candida. HLP expression is regulated by phenotype switching in C. glabrata and coincides with the hemolytic activity of the phenotype.