METHOD OF CONTROLLING THE BINDING OF CALMYRIN TO PRESENILIN
摘要
The present invention describes a calcium-binding myristoylated protein with homology to calcineurin B which interacts preferentially with presenilin 2 protein. Also, the present invention relates to methods that alter protein-protein interaction of the calcium-binding myristoylated protein with presenilin 2 thereby reducing deleterious effects of the protein-protein interaction, such as apoptosis. The present invention further relates to introducing and expressing a mutant presenilin 2 protein or mutant calcium-binding myristoylated protein to modulate cell functions relating to calcium signaling and apoptosis.
申请公布号
WO0196361(A1)
申请公布日期
2001.12.20
申请号
WO2001US18838
申请日期
2001.06.11
申请人
UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE;MONTEIRO, MERVYN, J.;STABLER, STACY, M.