发明名称 |
A NOVEL PROCESS FOR PREPARING SALMETEROL |
摘要 |
Accordingly, the present invention provides a process for the preparation of a compound of formula (I) or a single enantiomer thereof, or a salt or a solvate thereof, wherein W is a chiral auxiliary or hydrogen and P<1> and P<2> are each independently selected from hydrogen or a protecting group, which comprises: a) treatment of a compound of formula (II), or a salt or a solvate thereof, wherein W is a chiral auxiliary and P<1> and P<2> are each independently selected from hydrogen or a protecting group, with a compound of formula (III); b) treatment of the resulting product with a reducing agent; c) if required, deprotection to yield the compound of formula (I), or a salt or solvate thereof. In particular there is provided a process for producing a substantially pure single enantiomer of salmeterol. |
申请公布号 |
WO0196278(A2) |
申请公布日期 |
2001.12.20 |
申请号 |
WO2001GB02624 |
申请日期 |
2001.06.13 |
申请人 |
GLAXO GROUP LIMITED;PROCOPIOU, PANAYIOTIS, ALEXANDROU |
发明人 |
PROCOPIOU, PANAYIOTIS, ALEXANDROU |
分类号 |
C07D319/08;C07B61/00;C07C213/00;C07C213/08;C07C215/34;C07C217/10;C07C225/16 |
主分类号 |
C07D319/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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