发明名称 |
Urokinase inhibitor, useful for treatment, prophylaxis or diagnosis of thromboembolic disease, comprising acylated 3- or 4-amidino-benzylamine derivative |
摘要 |
A novel urokinase inhibitor comprises an acylated 3- or 4-amidino-benzylamine derivative (I). A novel urokinase inhibitor comprises an acylated 3- or 4-amidino-benzylamine derivative of formula (I). X = CH or N; R1 = H, 1-8C alkyl or -(CH2)nOH; n = 1-5; R2 = H or 1-8C alkyl; R3 = 1-8C alkyl or -(CH2)n-OR6; R4 = SO2R', COR', COOR' or H; R5 = H, OH, COR or COOR; R, R6 = 1-16C alkyl or (all optionally substituted) aryl, heteroaryl, aralkyl or heteroaralkyl; R' = as R; or an adamantyl or camphor residue; the amidino group is in the 3- or 4-position.
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申请公布号 |
DE10029014(A1) |
申请公布日期 |
2001.12.20 |
申请号 |
DE20001029014 |
申请日期 |
2000.06.15 |
申请人 |
FRIEDRICH-SCHILLER-UNIVERSITAET JENA |
发明人 |
STUERZEBECHER, JOERG;STEINMETZER, TORSTEN;KUENZEL, SEBASTIAN;SCHWEINITZ, ANDREAS |
分类号 |
C12N9/99;A61K9/02;A61K9/08;A61K9/16;A61K9/20;A61K9/28;A61K9/48;A61K9/70;A61K31/18;A61K38/00;A61P35/00;A61P43/00;C07K5/06;(IPC1-7):C07K5/06;A61K49/00 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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