发明名称 |
PROCESS FOR PRODUCING SIMVASTATIN |
摘要 |
A process for manufacturing Simvastatin is provided comprising reacting lovastatin with an organic boronic acid to produce a derivative of lovastatin with a hemiboronate group attached to the C-4 carbon of the pyranyl group, methylating the 2-methylbutyryloxy group on the lovastatin derivative to form a 2,2-dimethylbutyryloxy group on the lovastatin derivative and thereafter removing the hemiboronate group to produce simvastatin.
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申请公布号 |
US2001053859(A1) |
申请公布日期 |
2001.12.20 |
申请号 |
US19960754677D |
申请日期 |
1996.11.21 |
申请人 |
MURTHY K. S. KESHAVA;HORNE STEPHEN E;WEERATUNGA GAMINI;YOUNG SHAWN |
发明人 |
MURTHY K. S. KESHAVA;HORNE STEPHEN E;WEERATUNGA GAMINI;YOUNG SHAWN |
分类号 |
C07D309/30;C07F5/02;(IPC1-7):C07D309/30;C0739/10 |
主分类号 |
C07D309/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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