The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from <i>Dermaphagoides</i> dust mite. In particular, the optimised codon polynucleotides encode a protein from <i>Dermaphagoides pteronyssinus</i>, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions comprising the expression of the codon optimised polynucleotides, and vectors and transformed host cells comprising them.
申请公布号
WO0196385(A1)
申请公布日期
2001.12.20
申请号
WO2001EP06483
申请日期
2001.06.07
申请人
SMITHKLINE BEECHAM BIOLOGICALS S.A.;BOLLEN, ALEX;JACOBS, PAUL;JACQUET, ALAIN;MASSAER, MARC, GEORGES, FRANCIS
发明人
BOLLEN, ALEX;JACOBS, PAUL;JACQUET, ALAIN;MASSAER, MARC, GEORGES, FRANCIS
