| 摘要 |
The invention is a radiolabelled ligand for introducing an Auger electron emitting radionuclide into the nucleus of a cancer cell. The ligand binds selectively to a cell surface receptor that is unique to a cancer cell or which is overexpressed on a cancer cell. An Auger electron emitting radionuclide is bonded to the ligand either directly or by means of a chelator. The radiolabelled ligand is internalized by the cell upon binding to the receptor, and a sufficient portion of the ligands so internalized are transported to the nucleus to provide a lethal dose of radiation to it. |
