| 发明名称 |
ENZYME-CLEAVABLE PRODRUG COMPOUNDS |
| 摘要 |
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavage sequences within the conjugate and methods of treating patients with prodrugs of the invention. |
| 申请公布号 |
WO0195945(A2) |
申请公布日期 |
2001.12.20 |
| 申请号 |
WO2001US18903 |
申请日期 |
2001.06.11 |
| 申请人 |
CORIXA CORPORATION |
发明人 |
NIEDER, MATTHEW, H.;DUBOIS, VINCENT;GANGWAR, SANJEEV;LOBL, THOMAS, J.;PICKFORD, LESLIE, B.;TROUET, ANDRE;YARRANTON, GEOFFREY, T. |
| 分类号 |
A61K31/704;A61K47/48;A61P29/00;A61P31/00;A61P35/00;A61P43/00 |
主分类号 |
A61K31/704 |
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