PROCESS FOR THE PREPARATION OF A PIPERAZINE DERIVATIVE

摘要

(2R)-1-[3,5-Bis (trifluoromethyl) benzoyl]-4-[2-[(2S)-2-(methoxymethyl) morpholino]ethyl]-2-(3-hydroxy-4-methyl- benzyl) piperazine dihydrochloride can be prepared from (2R)-4-benzyl-1-[3,5-bis (trifluoromethyl) benzoyl]-2-(3- hydroxy-4-methylbenzyl) piperazine via debenzylation, N-alkylation, and conversion into hydrochloride.