| 摘要 |
Pyrrolidinyl, furanyl or thienyl-substituted thiazole derivatives (I) are new. Pyrrolidinyl, furanyl or thienyl-substituted thiazole derivatives of formula (I) are new. X = H, halo, alkyl, alkoxy, alkenyloxy, NO2, CN or optionally substituted phenyl; Y = halo, alkyl, alkoxy, alkenyloxy, haloalkyl, haloalkenyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, optionally substituted phenyl or optionally substituted phenoxy; T = N-D, O or S; A = H, or alkyl, alkenyl, alkoxyalkyl, polyalkoxyalkyl or alkylthioalkyl (all optionally substituted by halo), optionally substituted, saturated or unsaturated cycloalkyl (optionally having at least one ring C replaced by a heteroatom), or aryl, aralkyl or heteroaryl (all optionally substituted by halo, alkyl, haloalkyl, alkoxy, haloalkoxy, CN or NO2); B' = H, alkyl or alkoxyalkyl; or A + B' = group completing an optionally substituted, saturated or unsaturated ring, optionally containing at least one heteroatom; D = H, or alkyl, alkenyl, alkynyl, alkoxyalkyl, polyalkoxyalkyl, alkylthioalkyl, saturated or unsaturated cycloalkyl (optionally having at least one ring C replaced by a heteroatom), aryl, aralkyl or heteroaryl; or A + D = optionally substituted group completing an optionally substituted, saturated or unsaturated ring, optionally containing at least one heteroatom; G = H, 1 equivalent of a metal atom, ammonium ion, -C(O)R1, -C(L)-MR2, -SO2R3, -P(L)R4R5 or -C(L)-NR6R7; L, M = O or S; R1 = alkyl, alkenyl, alkoxyalkyl, polyalkoxyalkyl or alkylthioalkyl (all optionally substituted by halo), cycloalkyl (optionally substituted by halo, alkyl or alkoxy and optionally interrupted by at least one heteroatom); or phenyl, phenylalkyl, heteroaryl, phenoxyalkyl or heteroaryloxyalkyl (all optionally substituted); R2 = alkyl, alkenyl, alkoxyalkyl or polyalkoxyalkyl (all optionally substituted by halo); or cycloalkyl, phenyl or benzyl (all optionally substituted); R3 = alkyl, haloalkyl, optionally substituted phenyl or optionally substituted benzyl; R4, R5 = alkyl, alkoxy, mono- or dialkylamino, alkylthio, alkenylthio or cycloalkylthio (all optionally substituted by halo), or phenyl, benzyl, phenoxy or phenylthio; and R6, R7 = H, or alkyl, cycloalkyl, alkenyl, alkoxy or alkoxyalkyl (all optionally substituted by halo); or phenyl or benzyl (both optionally substituted); or NR6R7 = ring (optionally interrupted by O or S). Independent claims are also included for the following: (1) preparation of (I); and (2) new intermediates of formula (II; COOR8 replaced by COOH or CN), (III) and (IV). R8 = alkyl; and W1 = H, halo, alkyl or alkoxy. |
