An affinity ligand is constructed from at least 3 domains: (1) a recognition domain, e.g. a 3-6 amino acid chain specific for a peptide region of a target; this may be discovered and/or optimised by fitting candidate structures or parts thereof to a model of the target in a computer memory; (2) an affinity domain, e.g. a domain capable of binding to a particular type of region of the target such as a glycosylation region; and (3) a flexible linker having a functional group enabling the ligand to be immobilised to a sensor surface to create a specific biosensor.
申请公布号
WO0166567(A3)
申请公布日期
2001.12.20
申请号
WO2001GB01011
申请日期
2001.03.08
申请人
CRANFIELD UNIVERSITY;CHEN, BEINING;DAY, RICHARD, MICHAEL;KARIM, KHALKU;TURNER, ANTHONY, PETER, FRANCIS
发明人
CHEN, BEINING;DAY, RICHARD, MICHAEL;KARIM, KHALKU;TURNER, ANTHONY, PETER, FRANCIS