Alzheimer's disease secretase,app substrates therefor,and uses therefor

摘要

A method for assaying hu-Aspl proteolytic activity comprises the steps of: (a) contacting hu-Asp 1 protein with an hu-Aspl substrate which is a peptide consisting of 50 or fewer amino acids and including the hu-Aspl cleavage site having the amino acid sequence GLALALEP, under acidic conditions, and (b) determining the level of hu-Asp 1 proteolytic activity.