SYNTHESIS OF THE FIRST PARAMAGNETIC AND ACTIVE ANALOGUE (EPM-2) OF THE MELANOCYTE STIMULATING HORMONE CONTAINING AMINO ACID-TYPE STABLE FREE RADICAL

摘要

The present invention relates to an alpha-melanocyte stimulating hormone (alpha-MSH) analogue, labeled with an amino acid-type paramagnetic spin probe, for example, Toac, or 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, and methods for the synthesis thereof. The preferred analogue of the invention, acetyl-Toac0-alpha-MSH (abbreviated as EPM-2) is the first such analogue that maintains entirely the natural alpha-MSH activity.