发明名称 THE USE OF GROWTH HORMONE SECRETAGOGUES TO TREAT SYSTEMIC LUPUS ERYTHEMATOSUS AND INFLAMMATORY BOWEL DISEASE
摘要 Disclosed are medicines for treating systemic lupus erythematosus and/or inflammatory bowel disease such as Crohn's disease or ulcerative colitis, which comprise a growth hormone secretagogue (GHS), prodrug thereof or a pharmaceutically acceptable salt of the GHS or the prodrug. More particularly, the GHS is a compound of the Formula I: (see formula I) (in which HET is a heterocyclic moiety; R3 is alkyl, etc.; R4 is H, alkyl, etc.; X4 is H or alkyl; R6 is bond, alkylene, etc.; R7 and R8 are each H, alkyl, etc.) or a prodrug thereof or a pharmaceutically acceptable salt of the GHS or the prodrug. Also disclosed are combinations of a GHS and a second therapeutic agent, where the second therapeutic agent is known to be beneficial in the treatment of systemic lupus erythematosus and/or inflammatory bowel disease such as Crohn's disease or ulcerative colitis; and kits and pharmaceutical compositions comprising such combinations.
申请公布号 CA2350857(A1) 申请公布日期 2001.12.19
申请号 CA20012350857 申请日期 2001.06.15
申请人 PFIZER PRODUCTS INC. 发明人 BUSCH, FRANK ROBERT;LEFKER, BRUCE ALLEN;PAN, LYDIA CODETTA
分类号 A61K45/00;A61K31/00;A61K31/437;A61K31/438;A61K31/444;A61K31/4706;A61K31/49;A61K31/4985;A61K31/519;A61K31/55;A61K31/573;A61K38/04;A61K38/27;A61K45/06;A61P1/00;A61P37/00;C07K5/02;C07K5/06;(IPC1-7):A61K31/437;A61P1/04;A61K38/05;A61P1/10;A61K31/498 主分类号 A61K45/00
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