发明名称 |
POLY(ADP-RIBOSE)POLYMERASE GENE |
摘要 |
<p>The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.</p> |
申请公布号 |
PL345334(A1) |
申请公布日期 |
2001.12.17 |
申请号 |
PL19990345334 |
申请日期 |
1999.06.04 |
申请人 |
BASF AG |
发明人 |
KOCK MICHAEL;HOEGER THOMAS;KROEGER BURKHARD;OTTERBACH BERND;LEMAIRE HANS-GEORG;LUBISCH WILFRIED |
分类号 |
A01K67/027;A61K38/00;A61K38/45;A61K48/00;A61K49/00;A61P43/00;C07K14/455;C12N1/15;C12N1/19;C12N5/10;C12N9/10;C12N15/09;C12N15/54;C12Q1/68;G01N33/53;(IPC1-7):C12N9/10 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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