T CELL RECEPTOR FUSIONS AND CONJUGATES AND METHODS OF USE THEREOF

摘要

Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention hav e been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are compris ed of high affinity antigen-specific TCR and biologically active proteins and/o r effector molecules. Also featured are methods of production of T cell recept or fusion and conjugate complexes as well as therapeutic compositions for use o f the complexes.